Wisma AmFIRST is nestled within SS7, Kelana Jaya, offering convenient access from Kuala Lumpur city centre via the North Klang Valley Expressway (NKVE), Lebuhraya Damansara-Puchong (LDP) and the Federal Highway. The property is within 10 minutes walking distance from the Glenmarie LRT station and 10 minutes driving distance from the Sultan Abdul Aziz Shah Airport (formally Subang Airport).

The surrounding area boasts a diverse mix of purpose-built office and commercial buildings, residential apartments and condominiums, detached houses and shopping malls. Notable landmarks in the vicinity include the MBPJ Stadium, Kelana Jaya Recreational Park and Royal Selangor Golf Club.